Newdirran Bifizen Nightdeveloped by an internationally Italian probiotic scientific research team. It is beneficial to the rebalancing of gut microbia, helping improve the mood condition and sleep quality.


  • Tackle mood problems from the Gut-Brain Axis
  • Reduces negative, depressive emotions
  • Improves sleep quality
  • Efficacy proven in human clinical studies
  • Contains melatonin and vitamin B12
  • Patented Technology (Allergen Free and Microencapsulation)
  • From Italy(14 sticks/box)


Newdirran®Bifizen Night provides potential benefit as an adjunctive supplement for major depressive disorder, and improvement of psychological well-being as well as sleep quality in healthy or at-risk individuals 

Bifizen Night: Tackle Mood Discorders from the Gut-Brain Axis

The Bifizen probiotics combination:

Lactobacillus rhamnosis LR06

Lactobacillus plantarum LP01

Lactobacillus fermentum LF16

Bifidobacterium longum BL04

  • Anti-inflammatory
  • Intestinal barrier integrity
  • Dysbiosis


Clinical Evidence of Bifizen  probiotics for improving mood and sleep 

In a double-blind, randomized, placebo-controlled study on healthy subjects, the probiotic group (n=18) received BifizenTM probiotic mixture and the control group (n=15) received placebo for 6 weeks, followed by a 3-week washout period. The probiotic group showed:


Significant reduction in depressive mood state, sense of anger, and fatigue

Significant improvement in sleep quality


as compared to the control group. [Marotta et al 2019]


Figure 2.   (A) Median Profile of Mood State (POMS) Depression subscale score,

(B) Median POMS Anger subscale score,

(C) Median POMS Fatigue subscale score, and

(D) Median Pittsburgh Sleep Quality Index (PSQI) score at different time points

(*P<0.017 within the experimental group).

For both scales, a higher score indicates poorer mood state (depression/anger/fatigue)/poorer sleep quality respectively. [Marotta et al 2019]


Serving direction:

1 stick per day, preferably 30 minutes before bedtime. Mix well with liquid below 37, consume immediately after dilution.


Newdirran® Bifizen Night Probiotics